Product Name: Cyclosporine (Cyclosporine A)
CAS: 59865-13-3
Chinese name: Cyclosporine
Chinese Synonyms: Cyclosporine; Cyclosporine; Cyclosporin A; Cyclosporin A; Antibiotic S; Cyclosporin A; Cyclanthrasporin A; Cyclosporin
English name: Cyclosporin A
English synonyms: ol27-400; s7481f1; sandimmun; sandimmune; ANTIBIOTIC S 7481F1; ANTIBIOTIC S 7481FI; CICLOSPORIN; CICLOSPORIN A
CAS number: 59865-13-3
Molecular formula: C62H111N11O12
Molecular weight: 1202.61
EINECS number: 200-835-2
Standard: USP
Natural / Synthetic:
Source of extraction: 1kg fixed price shading, sealed
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 1KG / aluminum can not be split
Ingredients: Ring [[(E)-(2S, 3R, 4R) -3-hydroxy-4-methyl-2- (methylamino) -6-octenoyl] -L-2aminobutyryl-N-methyl Glycyl-N-methyl-L-leucine-L-valyl-N-methyl-L-leucine-L-alanyl-D-alanyl-N-methyl- L-Leucyl-N-Methyl-L-Leucyl-N-Methyl-L-Valyl]. Based on the dry product, the cyclosporine (C62H111N11O12) must not be less than 98.5%.
Physical and chemical properties: white or almost white powder; odorless. This product is very soluble in methanol, ethanol or acetonitrile, soluble in ethyl acetate, soluble in acetone or ether, almost insoluble in water.
Category: Pharmaceutical raw materials
Industry: Pharmaceutical
Field: Immunosuppressants
Extended products: cyclosporine oral solution, cyclosporine soft capsules, pills, oral solution
Application: It is mainly used for anti-rejection reaction of liver, kidney and heart transplantation. It can be used with adrenal cortex hormones and can also be used for the treatment of some immune diseases.
Usage and dosage: Oral: The dosage depends on the condition of the patient. The first dose before general organ transplantation is 14 to 17.5 mg per kilogram of body weight per day. It is taken orally 4 to 12 hours before surgery. 2 weeks, and then according to the concentration of creatinine and mountain blood plasma, weekly reduction of 5%, until the maintenance amount is 5 to 10 mg per kg of body weight per day. At the same time give hormone adjuvant therapy. The oral solution must be diluted with milk, chocolate or orange juice before taking it. The temperature is preferably 25 ° C. After opening the protective cover, use the straw to suck out the required amount of mountain (requires accuracy) from the container, and then put it into a glass cup containing milk, chocolate or orange juice (plastic cups are not available). After the medical solution is diluted and stirred, Drink immediately, and then clean the glass with milk, etc. to ensure accurate dosage. Before putting the used straw back into place, it must be wiped dry with a clean dry towel. Do not wash with water or other solutions to avoid turbidity of the mountain clear medicine solution.
Application: In addition to immunosuppression during transplantation, it can also be used to treat psoriasis, severe atopic dermatitis, pyoderma gangrenosum, chronic autoimmune urticaria, and the like Rheumatoid arthritis and other related diseases, but usually only used for more serious diseases. In the United States, ophthalmic emulsions are often used to treat dry eye. There are many studies on the use of cyclosporine in autoimmune diseases, and sometimes there are cases of animal drugs, especially hemolytic anemia with excessive immune regulation
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